Protective role of berberine on ulcerative colitis through modulating enteric glial cells–intestinal epithelial cells–immune cells interactions
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چکیده
منابع مشابه
The protective role of glycyrrhizin on ethanol- damaged B92 glial cells in vitro
Background and Purpose: Glycyrrhizin is one of the most important pharmacological compounds of the Licorice plant. The purpose of this study was to investigate the protective effects of glycyrrhizin on the B92 glial cells after treatment with ethanol. Materials and Methods: B92 cells were obtained from the Pasteur institute cell bank of Iran, (1×106 cell/ml) were transferred to 96 plates and in...
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Ulcerative colitis (UC) is a chronic non-specific inflammatory disease affecting the mucosa and the submucosa of the colon, and is characterized by alterations of gut functions which influence the clinical symptoms (Fiocchi, 1998; Reddy et al., 1991; Spriggs et al., 1951). Although reports showed morpho-functional abnormalities of the enteric nervous system in UC patients, the available literat...
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BACKGROUND Intestinal epithelium is essential for maintaining normal intestinal homeostasis; its breakdown leads to chronic inflammatory pathologies, such as inflammatory bowel diseases (IBDs). Although high concentrations of S100A9 protein and interleukin-6 (IL-6) are found in patients with IBD, the expression mechanism of S100A9 in colonic epithelial cells (CECs) remains elusive. We investiga...
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The inflammasomes induce maturation of pro-interleukin-1β (IL-1β) and pro-IL-18. We investigated roles of the NLRP3 inflammasome in the pathogenesis of ulcerative colitis (UC). After induction of oxazolone-induced colitis, a mouse UC model, colonic tissues were assayed for inflammatory mediators. Histological studies were performed on inflamed colonic tissue from mice and UC patients. Histologi...
متن کاملProtective role of appendicectomy on onset and severity of ulcerative colitis and Crohn's disease.
BACKGROUND AND AIMS Recent studies on appendicectomy rates in ulcerative colitis and Crohn's disease have generally not addressed the effect of appendicectomy on disease characteristics. The aims of this study were to compare appendicectomy rates in Australian inflammatory bowel disease patients and matched controls, and to evaluate the effect of prior appendicectomy on disease characteristics....
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ژورنال
عنوان ژورنال: Acta Pharmaceutica Sinica B
سال: 2020
ISSN: 2211-3835
DOI: 10.1016/j.apsb.2019.08.006